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ZAP70抗原,zeta相關(guān)蛋白70抗原

更新時間:2024-11-05點擊次數(shù):160

Recombinant human ZAP70   

ZAP-70; ZAP 70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein. 

濃度:1mg/ ml

來源:Recombinant Human

純度:≥90% SDS-PAGE

表達系統(tǒng):Baculovirus infected Sf9 cells

標簽:GST tag N-Terminus   

蛋白長度:Full length protein

內(nèi)毒素水平:<1.000 Eu/µg

純化方法:HPLC

應用:SDS-PAGE,Western blotELISA

Biological activity,immunology research

保存:-20

保質(zhì)期:1

Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.Expressed in T- and natural killer cells.Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.The SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH.



多克隆抗體:

產(chǎn)品名稱:Rabbit Anti-ZAP70 antibody

Rabbit Anti-ZAP70 

別名:ZAP-70; ZAP 70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein.          

來源:Rabbit

克隆類型:Polyclonal

濃度:1mg/ml

亞型:IgG

反應:Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Chicken,Dog,GuineaPig,Horse)

應用: WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

理論分子量:68kDa

免疫原:KLH conjugated synthetic peptide derived from human ZAP70

保存:-20
保質(zhì)期:1

 

 單克隆抗體

產(chǎn)品名稱:Anti-ZAP70 antibody

Mouse Anti-ZAP70

別名:ZAP-70; ZAP 70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein.       

來源:Mouse

克隆類型:Monoclonal

濃度:1mg/ml

亞型:IgG

反應:Human

應用: WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500  

反應:  Human

理論分子量:68kDa

免疫原:KLH conjugated synthetic peptide derived from human ZAP70

保存:-20
保質(zhì)期:1

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

 



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